“Uninhibited behaviours” is listed as a possible side effect for Effexor by it’s manufacture, Pfizer. But what is uninhibited behavior? Is it problematic? Well, yes… According to Pfizer, compulsive gambling and sexual misconduct are covered by the term, “uninhibited behaviours”.
A warning… But is it enough? A patient responds:
“How am I supposed to know what an ‘uninhibited behaviour’ was?” he said. “What a cloaking of an evil thing is that? That could be me parachuting or hang gliding or running down the beach with Speedos on! How was I to know it was going to be the type of addictive behaviours that would ruin my life?”
Efexor, first introduced to the American market in 1993, is now well established as one of Australia’s most commonly prescribed anti-depressant medications with more than 1.2 million prescriptions serviced in Australia in the past 12 months. At low and moderate doses, it acts only on the brain’s mood control neurotransmitters, serotonin and norephinephrine. But at high doses of over 300mg a day it also effects a third neurotransmitter called dopamine, which is responsible for reward-driven behaviours and has been associated with risk-taking behaviour and addiction.
It’s this dopamine effect that can cause problems, according to world-renowned psychiatrist, psychopharmacologist and author Dr David Healy. “When Efexor is taken at high dosages it triggers a flood of dopamine and becomes what we call a ‘dopamine agonist’. This can be responsible for the types of dangerous impulsive behaviours.”
Read the full story on RxISK.org: Gambling With Antidepressants